Bata Breattive Chidzidzo: PRR-based Ropa Ctdna Metdna Tekinoroji inovhura nguva itsva yeMRD kuongororwa kweColorel cancer

Nguva pfupi yadarika, Jama Oncology (kana 33.012) Yakakosha Kutsvaga Mhedzisiro yeFithani Hot kuvenga Tumor DNA methylation uye kufungira njodzi) ". Ichi chidzidzo ndicho chidzidzo chekutanga mulders Chidzidzo ichi chakanyatsoongororwa nejongosi uye vatsanangudzo, uye chakanyorwa sepepa rekurudzira iri, uye purofitera kubva kuSpain neProfesa Ajay Chidzidzo ichocho chakataurwawo neGenomeweb, anotungamira maBeokical media muUnited States.

Colorel cancer (CRC) iganda rakajeka rinokuvadza regastrointestinal turakiti muChina. 2020 International Agency Yekutsvagisa PaCancer (IARC) Data Ratidza kuti 555,000 Makesi muChina account yeanenge 1/3 yenyika, ine huwandu hwenyika 286,000 Rufu Account yeanenge 1/3 yenyika, chinzvimbo sechishanu chakajairika chikonzero che cancer kufa kuChina. Chikonzero chechishanu cherufu muChina. Zvinokosha kuti pakati pevarwere vakawona, tnm matanho i, II, III uye IV iri 18.6%, 46,5%, 30,7% uye 8.2% zvichiteerana. Vanopfuura 80% yevarwere vari pakati uye vanononoka kusvika pamatanho, uye 44% yavo vane panguva imwe chete kana kupfuma, kuisa pangozi yevagari vedu uye kukonzera mutoro wehupfumi uye hupfumi. Zvinoenderana nehuwandu hweNational Cancer Concer Concer Cancer Cancer Commency Kurapa muChina Inenge 6.2% yehutano Mukati megore rekuongorora rinogona kutora makumi matanhatu muzana yemari yemhuri. Varwere vechanza vari kutambura nechirwere uye zvakare mukumanikidzwa kukuru kwehupfumi [2].
Makumi mapfumbamwe muzana eColorel cancer Lesions inogona kubviswa kuvhiringidzika, uye iyo bundu raionekwa, iyo yakakwira mwero wekupukunyuka kwemakore mashanu mushure mekurapa kwekuvhiya kwekuvhiya. Mitero yemakore mashanu yekupona yeColorel cancer muChinese muChinese ndeye 90.1%, 72,6%, 53.8% uye 10.4% yeThe matanho i, II, III neII, zvichiteerana.
Chirwere chinosara chakasara (mrd) chikuru chinokonzeresa tumor kudzokorora mushure mekurapa kwakanyanya. Mumakore achangopfuura, tekinoroji yemitambo yakasimba yerudzi rwakasimba yasvika nekukurumidza, uye akati wandei zvidzidzo zvinorema uye zvekupindirana zvakaratidza kuti postoperative mr mamiriro anogona kuratidza njodzi yekudzoreredza cancer yeColorel cancer. Kuedza kweCTDA kune zvakanakira kuve zvisina kunaka, zviri nyore, nekukurumidza, neyekuwedzera kukurukurirana uye kukunda tumor heterogeneity.
Iyo US NCCP nhungamiro yeColon Cancer uye neChinese CSCO Tercer Commency Cancer Yakatarisana neCancer uye inofungidzira kuti inobatsira zvisarudzo zvekurapa kune varwere vane stage? Nekudaro, zvakawanda zviripo zvidzidzo zvinotarisisa zveCTDNE MUCHITSAUKO PAKATI PAKUTI SEQUGENCE TEXCOGY (NGS), iyo Yakareba Yakatungamira, Yakatadza Kushaikwa Kwemarudzi Ekupedzisira uye Kuwanda Kwevarwere veCommer.
Panyaya yeStage III Colorel Commeners Varwere, NGS-based CTDna Dynamic yekutarisa inodhura kusvika kumadhora zviuru gumi pakushanya kamwe chete uye kunoda nguva yekumirira inosvika vhiki mbiri. Neye multigene methylation bvunzo muchidzidzo ichi, Colonaiq ®, varwere vanogona kuve neDynamic Ctdna vanotarisa pane chegumi chemutengo uye utore mushumo mudiki semazuva maviri.
Maererano nemazana mashanu ezviuru emakore eColorel cancer muchina gore rega rega.
Zvinogona kuoneka kuti mhedzisiro yekutsvagisa ine kukosha kwakakosha kwesainzi uye kwakakosha kukosha. Kuburikidza neakakura-zviyero zvekiriniki zvidzidzo, zvakaratidza kuti PRR-based Rove Ctdnane Methcer Cancer Cancer Cances Chidzidzo ichi chakavakirwa paColonaiq ®, general-gene methylation bvunzo cancer yakagadzirwa nekiriniki yekunyora mukutanga kuongororwa uye kuongororwa kwakasimbiswa nechidzidzo chepakati chechiriniki.
Gastroenterology (IF33.88), nhoroondo dzepamusoro-soro mumunda wezvirwere zveGastroint. Kuongororwa kweColorel Cancer, uye Pakutanga kuongorora iyo zvakare inoongorora iyo iyo inogona kunyorera iyo yekunyorera mukuongorora kweiyo colorel cancer.

Kuenderera mberi nekushandisa kiriniki yekushandisa kweCTIDNALLATE mukunhuhwirira kwekutarisa Kurapa kweDynamic Ropa CTDna Kuedza.
Kutanga, zvakaonekwa kuti kuongororwa kweCTDna kunogona kufanotaura nenjodzi yekudzokorora muColorel Cancer Varwere Pakutanga, zviri zviviri uye zviri zviviri uye kutanga zvadzora. Varwere veCTDNA-yakanaka vaine mukana wepamusoro wekudzokorora kwekudzokorora pane preoperative CTDNA-VAKAWANDA VAKAWANDA (40%> 4.7%). Yekutanga Postiperative Ctdna Kuedza Kunofungidzirwa Kuti Ukanyatso Kukwana Njodzi: Mwedzi mumwe mushure mekutengeserana kwakasimba, varwere vakanaka vaiva 175,5 nguva vanogona kudzokorora kupfuura varwere vakaipa; Chikwata icho chakawanikwawo chakabatanidzwa CTDNATION uye CEA Kuongororwa zvishoma kuita mukutsvaga kwekudzokorora (AUC =
Clinical System Inosanganiswa Nezve Njodzi Parizvino Parizvino iri Ngozi Huridzi Varwere, uye muChidimbu Hukuru hwevarwere vachiri kudzoka [4], uye pane kudiwa kwekurapa kwekurapa uye pasi-kurapwa pamwe chete. Zvichibva pane izvi, timu yakadzivirirwa varwere IIII Colored cancer mune dzakasiyana-subgroups Ongororo yakawana kuti varwere vari muzvikamu zvepamusoro-subgroup reCTDNA-VAKAWANDA VAKAWANDA vakave nemutengo wakaderera kana vakagamuchira mwedzi mitanhatu yekuprapy yekurapa. Mune yakadzika-njodzi subgroup of CTDNA-VAKAWANDA VAKAWANDA, pakanga pasina musiyano wakakosha pakati pekutenderera kwekurapa kwekurapa uye zvabuda murwere; Nepo varwere veCTDN-VAKAWANDA vaive neyakanyanya nani prognosis kupfuura CTDNA-yakanaka varwere uye kwenguva refu yekudzosera nguva yekudzokorora (RFF); Nhanho i uye yakaderera-njodzi yengozi II II Colored Cancer vese Ctdna-varwere vasina kunaka havana kudzokorora mukati memakore maviri; Naizvozvo, kubatanidzwa kweCTDNA nemakiriniki maficha anotarisirwa kuenderera mberi nekuwedzera njodzi kurwadzisa uye zviri nani kufembera kudzokorora.

Mufananidzo 1. Plasma Ctdna kuongororwa kuPom1 yekukurumidza kuona colorectal cancer yekudzokorora
Zvimwe zvinoitika zveDynamic CTDNESS yakaratidza kuti njodzi yekudzokorora yaive yakanyanya kurapa kana kuti yakanyanya kurapa. mukana wekukwezva kwekutanga kwekutsvaga kwechirwere uye kupindira nguva nenguva.

Mufananidzo 2. Ctdna kuongororwa zvichibva pane refuitudinal cohort kuti uone colorectal cancer yekudzokorora

"Chiverengero chikuru chekududzira mishonga yekokonesi inotungamira chirango, kunyanya kuongororwa kweCTDTING

Iko mukana wekusarudza DNA metration seyekucherechedzwa kweiyo mucherechedzo pamusoro pekuongororwa kwetsika, uye zvinodzivisa zvenhema zvekuona zveSomatic muutsions
Ichi chidzidzo uye zvimwe zvinoenderana nezvidzidzo zvinoenderana neCTDA
Iyo munda weMRD iri kukurumidza kubuda neyakawandisa, yakanyanya kujairika uye yakanangana neEpignetics (DNA metgmentomics) uye genomics Tinotarisira kuti ColonaiQ ® ® inoenderera mberi kuronga zviyero zvakakura zvechikamu uye inogona kuve chiratidzo chitsva cheMRD kuongororwa izvo zvinosanganisa kuwanikwa, kugona kushandiswa uye kunogona kushandiswa zvakanyanya mumuitiro wekuchinja. "
Mareferensi
. Jama Oncol. 2023 Kubvumbi 20.
[2] "Chirevo cheColorel Cancer Chirwere Muvanhu veChinese: Zvakachinja mumakore achangopfuura here? , Chinyorwa cheChinese cheEpidemiology, Vol. 41, Nha. 10, Gumiguru 2020.
[3] Tarazona n, Gimeno-Valience F, Gambardella v, et Al. Inotarisirwa Inotevera-Chizvarwa Kutenderera Kwekutenderera-Tumor DNA Yekutsvaga Misungo Yemahara Muchirwere Colon Colon Colon. Ann oncol. Mbudzi 1, 2019; 30 (11): 1804-1812.
[4] Tatie J, André t, auclin E. Kunatsiridza Adjdu prapy yeasina-metastatic cancer, zviyero zvitsva nemaonero. Cancer inobata Zvakare 2019; 75: 1-11.