Varwere vekenza yemapapu, kuongororwa kweMRD kunodiwa here?

MRD (Minimal Residual Disease), kana kuti Minimal Residual Disease, nhamba duku yekenza masero (masero emukenza asingapinduri kana kuti anoramba kurapwa) anoramba ari mumuviri mushure mekurapa kenza.
MRD inogona kushandiswa sebiomarker, ine chigumisiro chakanaka chinoreva kuti maronda akasara anogona kuonekwa mushure mekurapa kenza (masero ekenza anowanikwa, uye masero emukenza asara anogona kushanda uye otanga kuwanda mushure mekurapa kenza, zvichiita kuti pave nekudzoka kwekenza. chirwere), nepo chigumisiro chisina kunaka chinoreva kuti zvipembenene zvakasara hazvionekwi mushure mekurapa kenza (hapana masero emukenza anowanikwa);
Zvinonyatsozivikanwa kuti kuongororwa kweMRD kunoita basa rakakosha mukuona varwere vekutanga-vasiri diki cell lung cancer (NSCLC) vari panjodzi huru yekudzokororwa uye mukutungamira kurapa adjuvant mushure mekuvhiyiwa kwakanyanya.
Mamiriro ezvinhu umo MRD inogona kushandiswa:

Kwegomarara remapapu rinoshanda rekutanga

1. Mushure mekuvhiyiwa kwakadzama kwevarwere vekenza yemapapu vasiri diki, MRD positivity inoratidza njodzi huru yekudzoka uye inoda kutarisisa kwepedyo. MRD yekutarisa inokurudzirwa mwedzi yese ye3-6;
2. Zvinokurudzirwa kuita perioperative kiriniki miedzo yeoperable isiri-diki sero cell cancer yemapapu zvichibva paMRD, uye kupa perioperative nemazvo nzira dzekurapa zvakanyanya sezvinobvira;
3. Kurudzira kuongorora basa reMRD mumhando mbiri dzevarwere, mutyairi gene positive uye driver gene negative, zvakasiyana.

Kune gomarara remapapu repamusoro-soro munharaunda isiri-diki

1.MRD yekuongorora inokurudzirwa kuvarwere mukuregererwa kwakakwana mushure mekugadzirisa chemoradiotherapy kune imwe nzvimbo yepamusoro-soro yekenza yemapapu yemapapu, iyo inogona kubatsira kuziva kufungidzira uye kugadzira mamwe mazano ekurapa;
2. Miedzo yekiriniki yeMRD-based consolidation therapy mushure me chemoradiotherapy inokurudzirwa kupa nzira dzakarurama dzekugadzirisa kurapa zvakanyanya sezvinobvira.
Kune gomarara remapapu repamusoro risiri diki
1. Pane kushaikwa kwezvidzidzo zvakakosha paMRD mune yepamberi isiri-diki cell kenza yemapapu;
2. Zvinokurudzirwa kuti MRD ionekwe kune varwere mukuregererwa kwakakwana mushure mehutano hwehutano hwepamusoro husina kenza yemapapu emapapu, iyo inogona kubatsira kutonga kufungidzira uye kugadzira mamwe maitiro ekurapa;
3. Zvinokurudzirwa kuita tsvakurudzo pamusoro peMRD-based treatments mazano kune varwere mukuregererwa kwakakwana kuti vawedzere nguva yekuregererwa kwakakwana sezvinobvira kuitira kuti varwere vawedzere zvikomborero zvavo.

Zvinogona kuonekwa kuti nekuda kwekushaikwa kwezvidzidzo zvakakosha pakuonekwa kweMRD mune yepamberi isiri-diki diki kenza yemapapu, kushandiswa kweMRD yekuona mukurapa kwepamusoro vasiri diki-diki kenza yemapapu varwere haina kunyatsoratidzwa.
Mumakore achangopfuura, kufambira mberi mune zvakanangwa uye immunotherapy kwakashandura maonero ekurapwa kwevarwere vane NSCLC yepamusoro.
Uchapupu huripo hunoratidza kuti vamwe varwere vanowana kurarama kwenguva refu uye vanototarisirwa kuwana kuregererwa kwakakwana nekufungidzira. Nokudaro, pasi pechirevo chokuti mamwe mapoka evarwere vane NSCLC yepamusoro zvishoma nezvishoma vakaziva chinangwa chekugara kwenguva refu, chirwere chekudzoka kwechirwere chave chiri nyaya huru yekliniki, uye kana MRD yekuongorora inogonawo kuita basa rinokosha mairi inofanirwa kuongororwa. mune kumwe kuedzwa kwekiriniki.