Varwere vane kenza yemapapu, kuongororwa kweMRD kunodiwa here?

MRD (Minimal Residual Disease), kana kuti Minimal Residual Disease, inhamba diki yemasero ekenza (masero ekenza asingapindure kana kuti anoramba kurapwa) anoramba ari mumuviri mushure mekurapwa kwekenza.
MRD inogona kushandiswa sechiratidzo chekuongorora, nemhedzisiro yakanaka zvichireva kuti maronda akasara anogona kuonekwa mushure mekurapwa kwegomarara (masero egomarara anowanikwa, uye masero egomarara akasara anogona kushanda otanga kuwanda mushure mekurapwa kwegomarara, zvichiita kuti chirwere chidzoke zvakare), nepo mhedzisiro isina kunaka ichireva kuti maronda akasara haaonekwe mushure mekurapwa kwegomarara (hapana masero egomarara anowanikwa);
Zvinozivikanwa kuti kuongororwa kweMRD kunoita basa rakakosha mukuona varwere vekenza yemapapu isiri diki (NSCLC) vari padanho rekutanga vari pangozi huru yekudzokera kuchirwere uye mukutungamira kurapwa kwe adjuvant mushure mekuvhiyiwa kwakanyanya.
Mamiriro ezvinhu ayo MRD inogona kushandiswa:

Kune kenza yemapapu inorapwa pakutanga

1. Mushure mekuvhiyiwa zvakanyanya kwevarwere vane kenza yemapapu vasiri masero madiki, kuvapo kweMRD kunoratidza njodzi huru yekudzoka kwechirwere uye kunoda kutarisirwa kwakanyatsoitwa. Kuongororwa kweMRD kunokurudzirwa mwedzi mitatu kusvika mitanhatu yega yega;
2. Zvinokurudzirwa kuita miedzo yekiriniki yekenza yemapapu isiri yemasero madiki inogona kuvhiyiwa zvichibva paMRD, uye kupa nzira dzekurapa dzakarurama dzeperioction sezvinobvira;
3. Zvinokurudzirwa kuongorora basa reMRD muvarwere vese vari vaviri, gene rekutyaira rine hutachiona uye gene rekutyaira risina hutachiona, zvakasiyana.

Kune kenza yemapapu isiri masero madiki iri kuitika munharaunda

1. Kuongororwa kweMRD kunokurudzirwa kuvarwere vari kuregererwa zvachose mushure mekurapwa neradical chemoradiotherapy yekenza yemapapu isiri diki iri munzvimbo yavo, izvo zvinogona kubatsira kuona fungidziro uye kugadzira mamwe maitiro ekurapa;
2. Miedzo yekiriniki yekurapa kwakavakirwa paMRD mushure mekurapa neradiotherapy inokurudzirwa kuti ipe nzira dzakarurama dzekurapa neconsolidation zvakanyanya sezvinobvira.
Kune kenza yemapapu isiri diki iri kukura
1. Hapana zvidzidzo zvakakosha paMRD mukenza yemapapu isiri diki;
2. Zvinokurudzirwa kuti MRD iongororwe muvarwere vari kuregeredzwa zvizere mushure mekurapwa kwechirwere chegomarara remapapu risiri remasero madiki, izvo zvinogona kubatsira kuona fungidziro yechirwere uye kugadzira mamwe maitiro ekurapa;
3. Zvinokurudzirwa kuita tsvakurudzo pamusoro penzira dzekurapa dzinoshandisa MRD muvarwere vari mukuregererwa zvizere kuti vawedzere nguva yekuregererwa zvizere sezvinobvira kuitira kuti varwere vagone kuwana mabhenefiti akawanda.

Zvinogona kuonekwa kuti nekuda kwekushaikwa kwezvidzidzo zvakakosha pakuonekwa kweMRD mukenza yemapapu isiri diki, kushandiswa kweMRD mukurapa varwere vekenza yemapapu isiri diki hakuna kuratidzwa zvakajeka.
Mumakore achangopfuura, kufambira mberi mukurapa kwakanangana nezvirwere zvemuviri kwakachinja maonero ekurapa kwevarwere vane NSCLC yepamusoro.
Humbowo huri kubuda hunoratidza kuti vamwe varwere vanorarama kwenguva refu uye vanotarisirwa kuti vazowana zororo rakazara nekutora mifananidzo. Saka, tichifunga kuti mamwe mapoka evarwere vane NSCLC yepamusoro akazadzisa zvishoma nezvishoma chinangwa chekurarama kwenguva refu, kutarisa kudzoka kwechirwere kwave nyaya huru yekiriniki, uye kana kuongororwa kweMRD kuchigonawo kuita basa rakakosha mairi kunofanirwa kuongororwa mune mimwe miedzo yekiriniki.