Vanhu Gumi Vanonyanya Kuonekwa MuSainzi Muzvisikwa:

Yunlong Cao wePeking University akasarudzwa kuti atsvage nezve coronavirus itsva

Musi wa15 Zvita 2022, Nature yakazivisa Nature's 10 yayo, runyorwa rwevanhu gumi vakave chikamu chezviitiko zvikuru zvesainzi zvegore, uye vane nyaya dzinopa maonero akasiyana pane zvimwe zviitiko zvakakosha zvesainzi zvegore rino rinoshamisa.

Mugore rematambudziko nekuwana zvinhu zvinonakidza, Zvisikwa zvakasarudza vanhu gumi kubva kuvanyanzvi venyeredzi vakatibatsira kunzwisisa kuvapo kwezvinhu zviri kure zvikuru muchadenga, kusvika kuvaongorori vakabatsira zvikuru muNew Crown nezvirwere zvetsoko, kusvika kuvanachiremba vakapfuura miganhu yekuisirwa nhengo, anodaro Rich Monastersky, mupepeti mukuru weNature Features.

Yunlong Cao anobva kuBiomedical Frontier Innovation Center (BIOPIC) paPeking University. Dr. Cao akapedza kudzidza paZhejiang University nedhigirii reBachelor muFizikisi uye akawana PhD yake kubva kuHarvard University's Department of Chemistry and Chemical Biology pasi peXiaoliang Xie, uye parizvino inyanzvi yekutsvagisa paBiomedical Frontier Innovation Center paPeking University. Yunlong Cao anga achitarisa pakuvandudzwa kwetekinoroji ye single-cell sequencing, uye tsvakiridzo yake yakabatsira kuteedzera kushanduka kwe coronavirus itsva uye kufanotaura zvimwe zvekuchinja kunotungamira pakuumbwa kwemarudzi matsva e mutant.

Musi wa18 Chivabvu 2020, Xiaoliang Xie/Yunlong Cao nevamwe vake vakaburitsa bepa mujenari reCell rine musoro unoti: “Ma antibodies ane simba rekudzivirira SARS-CoV-2 akaonekwa nekuwedzera kwemasero eB evarwere vanopora” Pepa rekutsvagisa iri.

Chidzidzo ichi chinoshuma mhedzisiro yekuongorora kwe coronavirus itsva (SARS-CoV-2) neutralizing antibody, iyo yakashandisa high-throughput single-cell RNA uye VDJ sequencing platform kuti ione 14 strongly neutralizing monoclonal antibodies kubva ku 8500 antigen-bound IgG1 antibodies muvarwere makumi matanhatu vakapora COVID-19.

Chidzidzo ichi chinoratidza kekutanga kuti kutevedzana kwemasero madiki kunogona kushandiswa zvakananga pakutsvaga mishonga uye kune mukana wekuva nzira inokurumidza uye inoshanda, iyo inovimbisa kuchinja nzira iyo vanhu vanoongorora ma antibodies ekudzivirira mavhairasi anotapukira.

Musi wa17 Chikumi 2022, Xiaoliang Xie/Yunlong Cao nevamwe vake vakaburitsa bepa rine musoro unoti: BA.2.12.1, BA.4 uye BA.5 escape antibodies dzinobva kuhutachiona hweOmicron mumagazini inonzi Nature.

Chidzidzo ichi chakawana kuti mhando itsva dzeOmicron mutant strains BA.2.12.1, BA.4 neBA.5 dzakaratidza kuwedzera kwekubuda kwemasoja emuviri uye kudzikira kukuru kwekubuda kweplasma muvarwere vakapora vane hutachiona hweOmicron BA.1.

Zvakawanikwa izvi zvinoratidza kuti mushonga weBA.1-based Omicron ungasave wakakodzera semushonga wekuwedzera njodzi pari zvino uye kuti ma antibodies anokonzerwa haazope dziviriro yakakura kubva kurudzi rutsva rwe mutant. Uyezve, dziviriro yeropa kubva kuhutachiona hweOmicron yakaoma zvikuru kuwana nekuda kwechiitiko che 'immunogenic' che coronavirus itsva uye kushanduka nekukurumidza kwenzvimbo dzekudzivirira immune escape.

Musi wa30 Gumiguru 2022, timu yaXiaoliang Xie/Yunlong Cao yakaburitsa bepa rekutsvagisa rine musoro unoti: Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution in the preprint bioRxiv.

Chidzidzo ichi chinoratidza kuti mukana weXBB kupfuura BQ.1 ungangove uripo nekuda kwekuchinja kuri kunze kwereceptor binding domain (RBD) yespinosin, kuti XBB inewo shanduko muzvikamu zve genome inokodha N-terminal structural domain (NTD) yespinosin, uye kuti XBB inokwanisa kunzvenga ma antibodies anodzivisa NTD, izvo zvinogona kuibvumira kutapurira vanhu vasina BQ.1 nezvimwe zvinhu zvine chekuita nayo. Zvisinei, zvakakosha kuziva kuti shanduko munzvimbo yeNTD dziri kuitika muBQ.1 nekukurumidza zvikuru. Dzidziso idzi dzinowedzera zvikuru kugona kwemarudzi aya kutiza ma antibodies anodzivisa masero anorwisa masero anokonzerwa nejekiseni uye hutachiona hwekare.

Dr. Yunlong Cao vakati panogona kunge paine dziviriro kubva kuXBB kana paine hutachiona hweBQ.1, asi tsvakiridzo yakawanda inodiwa kuti pave nehumbowo hweizvi.

Kuwedzera kuna Yunlong Cao, vamwe vanhu vaviri vakaiswa pane runyorwa urwu nekuda kwemabasa avo akanaka muhutano hweveruzhinji pasi rose, Lisa McCorkell naDimie Ogoina.

Lisa McCorkell muongorori weLong COVID uye semumwe wevakatanga sangano rePatient-Led Research Collaborative, akabatsira kusimudzira ruzivo nekubhadhara mari yekutsvagisa nezvechirwere ichi.

Dimie Ogoina chiremba wezvirwere zvinotapukira paNiger Delta University muNigeria uye basa rake padenda retsono muNigeria rakapa ruzivo rwakakosha mukurwisa denda retsono.

Musi wa10 Ndira 2022, University of Maryland School of Medicine yakazivisa chirongwa chekutanga chepasi rose chekugadzira moyo wenguruve chakagadziriswa majini mumunhu mupenyu, apo murwere wemwoyo ane makore 57 ekuberekwa David Bennett akapihwa chirongwa chekuisirwa moyo wenguruve chakagadziriswa majini kuti aponese hupenyu hwake.

Kunyangwe moyo wenguruve uyu wakangowedzera hupenyu hwaDavid Bennett nemwedzi miviri chete, wave kubudirira kukuru uye kufambira mberi kwenhoroondo mumunda we xenotransplantation. Muhammad Mohiuddin, chiremba wekuvhiya akatungamira timu yakapedza kuisirwa moyo wenguruve wakagadziriswa majini nevanhu, pasina mubvunzo akadomwa pane runyorwa rweVanhu Gumi Vakanakisisa veGore reNature.

Vamwe vakati wandei vakasarudzwa nekuda kwekufambira mberi kwesainzi inoshamisa uye kufambira mberi kwakakosha kwemutemo, kusanganisira nyanzvi yezvemuchadenga Jane Rigby weNASA's Goddard Space Center, uyo akaita basa guru mubasa reWebb Space Telescope rekuisa teresikopu muchadenga nekushanda nemazvo, zvichitora kugona kwevanhu kuongorora zvakasikwa kusvika padanho idzva uye repamusoro. alondra Nelson, seMutungamiriri weUS Science and Technology Policy weHofisi yeSainzi neTekinoroji, akabatsira hutungamiriri hwaMutungamiri Biden kugadzira zvinhu zvakakosha zvehurongwa hwavo hwesainzi, kusanganisira mutemo wekuvimbika kwesainzi uye nhungamiro itsva pamusoro pesainzi yakavhurika. Diana Greene Foster, muongorori wekubvisa pamuviri uye demographer paYunivhesiti yeCalifornia, San Francisco, akapa data rakakosha pamusoro pemhedzisiro inotarisirwa yesarudzo yeDare Repamusorosoro reUS yekudzora dziviriro yepamutemo yekodzero dzekubvisa pamuviri.

Kunewo mazita ari pamusoro pegumi regore rino ane chekuita nekukura kwekushanduka kwemamiriro ekunze nedzimwe njodzi dzepasi rose. Ndivo: António Guterres, Munyori Mukuru weSangano reNyika Dzepasi Pose, Saleemul Huq, Mutungamiriri weInternational Centre for Climate Change and Development muDhaka, Bangladesh, naSvitlana Krakovska, Mutungamiriri wechikwata cheUkraine kuUN Intergovernmental Panel on Climate Change (IPCC).