Vanhu Vepamusoro Gumi muSainzi:

Peking University's Yunlong Cao yakatumidzwa kutsvagurudzo yekoronavirus

Musi wa15 Zvita 2022, Zvisikwa zvakazivisa Masikirwo ayo gumi, runyorwa rwevanhu gumi vanga vari chikamu chezviitiko zvikuru zvesainzi zvegore, uye vane nyaya dzinopa maonero akasiyana pane zvimwe zvakakosha zviitiko zvesainzi zvegore rino rinoshamisa.

Mugore rematambudziko uye zvinhu zvinofadza zvakawanikwa, Zvisikwa zvakasarudza vanhu gumi kubva kune vezvenyeredzi vakatibatsira kunzwisisa kuvapo kuri kure zvikuru kwepasi, kuvatsvakurudzi vakabatsira muchirwere cheNew Crown uye monkeypox, kuvarapi vakaputsa miganhu yekusimwa kwenhengo, anodaro Rich Monastersky, mupepeti-mukuru weZvinhu Zvakasikwa.

Yunlong Cao anobva kuBiomedical Frontier Innovation Center (BIOPIC) paPeking University. Dr. Cao akapedza kudzidza kubva kuZhejiang University aine Bachelor's degree in Physics uye akawana PhD yake kubva kuHarvard University's Department of Chemistry and Chemical Biology pasi peXiaoliang Xie, uye iye zvino ari Research Associate paBiomedical Frontier Innovation Center paPeking University. Yunlong Cao anga achitarisa mukuvandudza tekinoroji yesero-sero, uye tsvagiridzo yake yakabatsira kuronda shanduko yemakoronavirus matsva uye kufanotaura mamwe machinjiro anotungamira mukugadzirwa kwematanho matsva.

Musi wa18 Chivabvu 2020, Xiaoliang Xie/Yunlong Cao et al. yakaburitsa bepa mujenari Cell rine musoro unoti: "Akasimba anodzivirira masoja ekudzivirira chirwere kubva kuSARS-CoV-2 akaonekwa nepamusoro-sero rimwe-sero sequencing yevanopora varwere 'maseru B" Bepa rekutsvagisa.

Chidzidzo ichi chinoshuma mhedzisiro yekoronavirus nyowani (SARS-CoV-2) inogadzirisa antibody skrini, iyo yakashandisa yakakwira-sero-sero RNA uye VDJ yekuteedzera chikuva kuratidza gumi nemana zvine simba rinodzora monoclonal antibodies kubva pamusoro pe8500 antigen-yakasungwa IgG1 masoja ekudzivirira chirwere mune makumi matanhatu akapora COVID-19 varwere.

Ongororo iyi inoratidza kekutanga kuti kutevedzana kwesero rimwe chete kwepamusoro-soro kunogona kushandiswa zvakananga kutsvaga zvinodhaka uye kune mukana wekuve nzira inokurumidza uye inoshanda, iyo inovimbisa kushandura nzira iyo vanhu vanovheneka nayo kudzivirira masoja ekudzivirira chirwere kuhutachiona hwehutachiona.

Musi wa17 Chikumi 2022, Xiaoliang Xie/Yunlong Cao et al. yakabudisa bepa rine musoro unoti: BA.2.12.1, BA.4 uye BA.5 masoja ekudzivirira chirwere anokonzerwa nehutachiona hweOmicron mujenari Nature.

Ichi chidzidzo chakawana kuti itsva subtypes yeOmicron mutant strains BA.2.12.1, BA.4 uye BA.5 yakaratidza kuwedzera kwekudzivirira kwekudzivirira uye kuderera kukuru kweplasma kupukunyuka mune vakadzorerwa Omicron BA.1-vakatapukirwa nevarwere.

Izvi zvakawanikwa zvinoratidza kuti BA.1-based Omicron vaccine inogona kunge isingachakodzeri sechinosimudzira muchimiro chemazuva ano chekudzivirira uye kuti masoja ekudzivirira chirwere anokonzereswa haape dziviriro yakakura kubva kune itsva mutant strain. Uyezve, kusadzivirirwa kwemombe kuburikidza nehutachiona hweOmicron kwakaoma zvakanyanya nekuda kweiyo 'immunogenic' chiitiko chekoronavirus nyowani uye nekukasira kushanduka kwemasaiti ekudzivirira immune.

Musi wa30 Gumiguru 2022, timu yaXiaoliang Xie/Yunlong Cao yakaburitsa bepa rekutsvagisa rakanzi: Yakadhindwa SARS-CoV-2 humoral immunity induces converging Omicron RBD shanduko mune preprint bioRxiv.

Ichi chidzidzo chinoratidza kuti mukana we XBB pamusoro peBQ.1 inogona kunge yakakonzerwa nechikamu chekuchinja kunze kweiyo receptor binding domain (RBD) ye spinosin, iyo XBB inewo kuchinja mune zvikamu zve genome encoding N-terminal structural domain (NTD) ye spinosin, uye kuti XBB inokwanisa kupukunyuka neutralizing antibodies kurwisana neNTD, iyo inogona kubvumira kuti iite infect. Zvisinei, zvakakosha kuziva kuti kuchinja munharaunda yeNTD kuri kuitika muBQ.1 pamwero wakakurumidza zvikuru. Shanduko idzi dzinosimudzira zvakanyanya kugona kweaya akasiyana kutiza masoja ekudzivirira ekudzivirira anogadzirwa nejekiseni uye kutapukira kwakare.

Dr. Yunlong Cao akati panogona kuva nekudzivirirwa kune XBB kana utachiona neBQ.1, asi imwe tsvakurudzo inodiwa kuti ipe uchapupu hweizvi.

Pamusoro peYunlong Cao, vamwe vanhu vaviri vakaita rondedzero yezvipo zvavo zvakatanhamara kumatambudziko ehutano hweveruzhinji, Lisa McCorkell naDimie Ogoina.

Lisa McCorkell muongorori ane Long COVID uye senhengo yekutanga yePatient-Led Research Collaborative, akabatsira kusimudzira ruzivo uye mari yekutsvagisa chirwere ichi.

Dimie Ogoina chiremba wechirwere chinotapukira kuNiger Delta University kuNigeria uye basa rake padenda retsoko muNigeria rakapa ruzivo rwakakosha mukurwisa denda remonkeypox.

Musi wa10 Ndira 2022, Yunivhesiti yeMaryland Chikoro cheMishonga yakazivisa nyika yekutanga yakabudirira kuisirwa jena-yakagadziriswa moyo yenguruve mumunhu mupenyu, apo murwere wemoyo wemakore makumi mashanu nemanomwe David Bennett akagamuchira gene-edited yenguruve yemoyo kuti aponese hupenyu hwake.

Kunyangwe moyo wenguruve uyu wakangowedzera hupenyu hwaDavid Bennett nemwedzi miviri, yanga iri budiriro huru uye chiitiko chenhoroondo mumunda wexenotransplantation. Muhammad Mohiuddin, chiremba anovhiya akatungamira chikwata chakapedzisa kuisirwa kwemoyo wenguruve kumunhu, pasina kupokana akadomwa kuzita reNature's Top 10 People of the Year.

Vamwe vakati wandei vakasarudzwa kusimudzira kubudirira kwesainzi kunoshamisa uye kufambiswa kwemitemo kwakakosha, kusanganisira nyanzvi yezvemuchadenga Jane Rigby weNASA Goddard Space Center, akaita basa rakakosha muchinangwa cheWebb Space Telescope chekupinza teresikopu muchadenga nekushanda nemazvo, zvichitora kugona kwevanhu kuongorora denga kusvika padanho idzva uye repamusoro. alondra Nelson, seUS Sainzi neTekinoroji Policy Acting Director weHofisi yeSainzi neTekinoroji, akabatsira hutongi hweMutungamiri Biden kugadzira zvinhu zvakakosha zvesainzi ajenda, kusanganisira mutemo wekuvimbika kwesainzi uye nhungamiro nyowani pasainzi yakavhurika. Diana Greene Foster, muongorori wekubvisa pamuviri uye anoona nezvehuwandu hwevanhu paYunivhesiti yeCalifornia, San Francisco, akapa ruzivo rwakakosha pamusoro pezvinotarisirwa kuita nemutongo weDare Repamusorosoro reUS wekupidigura kuchengetedzwa kwemutemo kwekodzero dzekubvisa pamuviri.

Pane mazita zvakare ari pamusoro pegumi epamusoro gore rino ane chekuita nekuvandudzwa kwemamiriro ekunze nemamwe matambudziko pasi rose. Ndivo: António Guterres, Munyori Mukuru weUnited Nations, Saleemul Huq, Mutungamiriri weInternational Center for Climate Change and Development muDhaka, Bangladesh, naSvitlana Krakovska, Musoro wenhume dzeUkraine kuUN Intergovernmental Panel on Climate Change (IPCC).