Phase III Data paChina Nyowani Nyowani Crown Dish mushonga muNejm Ratidza kushanda kusakwana kusiri kuderera kune paxhovid

Mukutanga kwemaawa 29 Zvita, nejm yakaburitswa online kiriniki itsva chikamu III kudzidza kweiyo New Chinese Coronavirus vv116. Mhedzisiro yacho yakaratidza kuti vv11 yakanga isiri yakaipa kupfuura paxlovid (nematovir / ritonavir) maererano neyakaenzana kiriniki kupora uye kuve nemashoma zviitiko zvinokanganisa.

Mufananidzo unobva: Nejm

Pakati pekudzoreredza nguva mazuva mana, zvinoitika zviitiko zvechiitiko 67.4%

VV106 IS NARALEICIED ANULELUE-NYIYO CORONOSVARUS (COV-COV-2) Drugbitor uye Wang ShanDoR

Muna 2021, chikamu chechipiri chekiriniki yeVV116 chakapera muUzbekistan. Mhedzisiro yeChidzidzo ichi yakaratidza kuti vv116 boka raigona kugadzirisa zviratidzo zvechirongwa uye zvakanyanya kuderedza njodzi yekufambira mberi kune fomu yakaoma uye kufa zvichienzaniswa neboka rekutonga. Zvichibva pamhedzisiro yakanaka yeiyi muyedzo, vv116 yakatenderwa muUzbekistan yekurapa kwevarwere vane mwero-kusvika-mishonga yezvinodhaka yakatenderwa pakushambadzira mhiri kwemakungwa muChina [1].

Ichi chikamu cheIII Clinical Kero Kuongorora kushanda uye kuchengetedzeka kweVV116 kupesana paxlovid yekutanga kurapwa kwevarwere nevarwere vane mwero kusvika pakati nepakati-19. Chinangwa chacho chaive chekuongorora kushanda uye kuchengeteka kweVV116 kupesana nePaligid pakurapa kwekutanga kwevarwere nevarwere vane mwero kusvika pakati nepakati-19.

Mufananidzo Tsime: Reference 2

Muedzo wechilticentre, wekuona-wakapofumadzwa, wakadzorwa, wevashandi vevakuru kuenderera mberi pakati pe4 Kubvumbi uye 2 May 2022 kuongorora kukodzera kwevatori vechikamu kubva kuShanghai, China. Pakupedzisira.

Migumisiro yeiyi kiriniki yekudzidza yakaratidza kuti kurapwa kwekutanga neVV116 yekupora kiriniki (nguva yekudzoreredzwa nePaxLoviod Boka (Hazard Ratio, 1.17; 95 kusvika 1.36;> 0.08).

Kuchengetedza kiriniki yekupora nguva

Yekutanga uye Secondary Efficity Inopedza (Kuongorora kwakakwana kwehuwandu)

Mufananidzo Tsime: Reference 2

Panyaya yekuchengetedza, vatori vechiremba vanogamuchira vv116 vakataura zvishoma zviitiko (67.4%) pane izvo zvinotevera zveGiredhi,

Zviitiko zvakashata (vanhu vakachengeteka)

Mufananidzo Tsime: Reference 2

Kupokana nemibvunzo

Musi waMay 23, 2022, Juniper anoburitsa kuti chikamu cheIII kunyoreswa Clincal Kudzidza kweVV116

Mufananidzo Tsime: Referensi 1

Panguva iyo nhoroondo yemuedzo ichishayiwa, kukakavara kwakapoteredza chidzidzo cheIII kwaive kaviri: Chekutanga, kwaive kusavapo kushandisa kweshoko rekutonga, kwaityiwa kuti zvingave zvakaoma kutonga zvinodhaka zvakanyanya; Kechipiri, makanga mune mibvunzo nezve kiriniki endpoints.

Iyo Clinsical Inclassion Criteria yeJuniper ndeye (i) yakanaka mhedzisiro yeiyo korona bvunzo, (ii) imwe chete kana ine mwero kana mwero mwero, uye (iii) varwere vakawanda vekutora kwakanyanya-19, kusanganisira rufu. Nekudaro, iyo chete clinary kiriniki endpoint ndeye 'nguva yekuchengetedza kiriniki kudzoreredza'.

Chingori chiziviso, musi waMay 14, Juniper yakadzokorora mafungiro ekiriniki nekubvisa imwe yekiriniki yekutanga miganhu, "chikamu chekutendeuka kuchirwere chakakomba kana kufa" [3].

Mufananidzo Tsime: Referensi 1

Iyi pfungwa huru dzekukakavara dzakanyatsogadziriswa mukudzidza kwakabudiswa.

Nekuda kwekukurumidza kubuda kweOmicron, kugadzirwa kwemahwendefa ePaxidhi hakuna kupedzwa kusati kwatanga kutongwa uye saka vaongorori vakatadza kuitisa tsika iyi vachishandisa mapofu mapofu, mapofu mapofu. Kana iri imwechete-bofu yekiriniki yekutongwa, Juniper akataura kuti protocol yakaitwa mushure mekutaurirana kwekutanga uye kuti mutsigiri achazongudza mishonga yezvinodhaka kusvikira iyo database yekupedzisira yakakiiwa pakupera kwekudzidza.

Kusvika panguva yekupedzisira kuongorora, hapana kana mumwe wevatori vechikamu mumuedzo anga aine rufu kana kufambira mberi kusvika pakubata kweVV116 mukudzivirira kufambira mberi kusvika pakufambira mberi kana kuderera kwechisimba-19 kana kufa. Iyo data yakaratidza kuti iyo inofungidzirwa kuti nguva yekusagadzikana kuti isimbe kurambidzwa kweChid-19-yakanangana nezviratidzo (95% ci, njodzi Hazvina kuoma kutsanangura kuti nei maitiro makuru e 'mwero wekushandurwa kwechirwere chakakomba kana rufu', iyo yakatanga kuiswa muedzo wekutongwa kusati kwasvika, rakabviswa.

Pana 182 May 2022, chinyorwa chinobuda zvinobuda muyero wekutanga wekutongwa kweVV116 mune varwere vane hutachiona hweOmicron.

Dhata kubva kuChidzidzo ichi yakaratidza kuti varwere vane hutachiona hweOmicron vakashandisa vic11o emazuva mashanu ekutanga bvunzo acid. Administration yeVV116 kune Varwere Vemarwere mukati meiyo nguva yekudzidza iyi (2-10 mazuva okutanga yakanaka nyukireki acid bvunzo) kuderedza nguva yekudzikamisa mune vese varwere. Panyaya yekuchengetedzwa kwezvinodhaka, hapana mhedzisiro yakaipa yakaonekwa muVV116 kurapwa kweboka.

Mufananidzo Tsime: Reference 4

Kune matatu matatu ekuenderera mberi miedzo paVV116, zviviri zvacho zviri phase III zvidzidzo pane zvinyoro-nyoro kune mwero covid-19 (Nct0542042, nct05582629). Imwe muyedzo yekuyera zvine mwero kuwanda-19 ndeyekuti multicent Interntre, yakasarudzika, mapofu-mapofu clintics kudzidza (NCT05279235) kuti uongorore uye kuchengeteka kweVV116 kuenzaniswa neyakaenzana kurapwa. Maererano nekuzivisa neJuniper, murwere wekutanga akanyoreswa uye akabvisirwa munaKurume 2022.

Image Source: mlinicletrilal.gov

Mareferensi:

[1] Junshi Biotech: Chiziviso pane chikuru kupedzisa nzvimbo yeIII yakanyorwa Clintics yekufunda yeVV116 persus paxlovid yekutanga kurapwa kwezvinhu zvine mwero kuverenga-19

. Xu, hao yin, zhren fu, li liing, lilly sun, heyu huang, linlin zen, zhijun zhu, wengong zhang, zhongxin wang. . Zvinobuda hutachiona & hutachiona 11: 1, mapeji 2636-2644.