Nhau - Muurayi Akavanzika muCanine WorldMalignant Hyperthermia

Varidzi vezvipfuyo vangave vakanzwa nezve canine malignant hyperthermia-chirwere chinouraya chenhaka chinowanzoitika kamwe kamwe mushure meanesthesia. Pakati payo, inobatanidzwa zvakanyanya neabnormalities muRYR1 gene,uyenucleic acid kuongororwandiyo kiyi yekuziva iyi genetic njodzi pachine nguva.

Nezvemaitiro ayo enhaka, kubvumirana kwesainzi ndiko kunoteveraautosomal dominant nhaka nekupinda kusina kukwana-kureva imbwa dzinotakura mutated gene dzinogona kusaratidza zviratidzo nguva dzose; kuratidzwa kunoenderana nezvinokonzeresa zvekunze uye mazinga ekutaura kwemajini.

Nhasi, ngatitorei zvakadzama kuti chirwere ichi chinoitika sei pasi peiyi genetic modhi uye izvo zvinokonzeresa zvingaite.

Chakavanzika Kuseri kweRYR1 Gene Kuenda Kunze Kudzora

Kuti tinzwisise nzira ye canine malignant hyperthermia, tinoda kutanga taziva "basa rezuva" reRYR1 gene-rinoita se "muchengeti wemagedhi e calcium channelsMumasero etsandanyama. Mumamiriro ezvinhu akajairika, imbwa painofamba kana kuti inoda kudhonzwa kwemhasuru, chiteshi chinodzorwa nejini reRYR1 chinovhura, chichibudisa maion calcium akachengetwa mumitsipa yemhasuru kuti atange kukonana.

hurongwa hwose hunoramba hwakarongeka uye hunodzorwa, pasina kuunza kupisa kwakanyanya.

Zvisinei, apo RYR1 gene mutates (uye autosomal dominant nhaka inoreva kopi imwe yakashandurwa inogona kuva pathogenic), uyu "muchengeti wegedhi" anorasikirwa nekutonga. Iyo inova yakanyanyisa kunzwa uye inowanzogara yakavhurika pasi pezvimwe zvinokurudzira, zvichiita kuti huwandu hukuru hwe calcium ion hufashamire zvisingadzoreki mumafibhi emhasuru.

Panguva ino, masero emhasuru anowira muchimiro che "overexcitationIzvi zvinopedza simba uye zvinobudisa kupisa kwakawanda. Sezvo imbwa dziine simba shoma rokubvisa kupisa, kana kupisa kwakanyanya kudarika kupera, kupisa kwemuviri kunogona kukwira mukati memaminitsi (kubva pa38-39°C kusvika pa41°C). kusaenzana kunokonzera kukanganisa kwezvinetso: kunyanya kushandiswa kwemisimba kunobereka lactic acid yakawanda uye creatine kinase, iyo inounganidza muropa uye inokuvadza nhengo dzakadai seitsvo (creatine kinase inogona kuvhara renal tubules) uye chiropa chemuscle fibers inogona kuputika pasi pekugadzirisa kunoramba kuripo, zvichiita kuti rhabdomyolysis iwedzere, iyo inokonzera rhabdomyolysis, rima-colored, uye marwadzo e-uriri-colored. Mhosva dzakakomba dzinogona kukura arrhythmia, hypotension, kukurumidza kufema, uye kutadza kwenhengo dzakawanda-pasina kupindira kwekukurumidzira panguva, chiyero chekufa chakanyanya kukwirira.

Pano tinofanira kusimbisa kupinda kusina kukwana: dzimwe imbwa dzinotakura RYR1 mutations asi dzinoratidza pasina zviratidzo muupenyu hwezuva nezuva nokuti gene expression inoda trigger. Chete kana zvimwe zvinokurudzira zvikaitika ndipo shanduko inogadziriswa uye nzira dzecalcium dzinoenda kunze kwekutonga. Izvi zvinotsanangura kuti sei vatakuri vazhinji vachiramba vaine hutano hwehupenyu hwese kana vasina kumbovhenekwa kune zvinokonzeresa-asi vanogona kusangana nekukasira kutanga kana kwatanga.

Zvitatu Zvikuru Zvinokonzera zveCanine Malignant Hyperthermi

Maitiro echeni anotsanangurwa pamusoro anowanzo kukonzerwa nemapoka matatu ezvikonzero:

1. Specific Anesthetic Agents (Primary Trigger)Chikonzero chakasimba zvikurusa chinosanganisira mimwe mishonga yokutindivadza—yakadai sehalothane, isoflurane, sevoflurane, uye depolarizing tsandanyama zvinozorodza se succinylcholine. Iyi mishonga inopindirana zvakananga neiyo mutated RYR1 gene, inowedzera kukanganisa nzira dze calcium. Clinical data inoratidza kuti inenge 70% ye canine malignant hyperthermia kesi inoitika panguva yekuvhiyiwa uchishandisa anesthetics aya, kazhinji mukati memaminitsi 10-30 mushure mekugadzirwa.Kupinda kusina kukwana kunoratidzwawo pano: dzimwe imbwa dzinotakura mutation dzinogona kusaita nemishonga iyi nekuda kwekusiyana kwekutaura kwegene kana simba remagetsi.

2. Kupisa Kwezvakatipoteredza uye Kuita KwenyamaTembiricha yepamusoro uye humidity nharaunda (semuenzaniso, mota dzinopisa dzakavharwa, mabhakoni ane zuva) inoderedza kupera kwekupisa. Kana imbwa ichiita basa rakasimba pasi pemamiriro ezvinhu akadaro, kupisa kwemetabolism kunowedzera zvakanyanya. Yakasanganiswa neRYR1 abnormalities, izvi zvinogona kumisa iyo mutated gene. Mhosva dzakataurwawo panguva yekufambisa nekuda kwekupisa, kushushikana, uye kufamba kwakapfava.

3. Yakanyanya Stress ResponseKukuvadzwa kwekuvhiya, kutya kamwe kamwe (semuenzaniso, kudzingirirwa nemhuka huru, mafirecrackers ane ruzha), kana kurwadziwa kwakanyanya (kutsemuka, kukuvara) kunogona kukonzera kuvhiyiwa kweadrenaline uye mamwe mahormone ekushushikana. Aya mahomoni anoita zvisina kunanga iyo yakashandurwa RYR1 gene, zvichikonzera kuburitswa kwecalcium. A Labrador inotakura shanduko yakambogadzira hyperthermia yakaipa nekuda kwekunetseka kubva pangozi yemotokari-muenzaniso wekupinda kusina kukwana kunokonzerwa nekunze kwekunze.

Zvinokosha kucherechedza kuti susceptibility zvakasiyana pakati pemarudzi.Labrador Retrievers, Golden Retrievers, Beagles, Vizslas, uye mamwe marudzi ane RYR1 mutation rates yakakwirira, nepo marudzi maduku akaita seChihuahuas nePomeranians ane nyaya shomanana dzakataurwa. Zera rinoitawo basa-imbwa diki (makore 1-3) dzine mhasuru yemetabolism yakawanda, zvichiita kuti dzisanyanya kunetseka kune zvinokonzeresa kupfuura imbwa dzakura.

Genetic Testing: Kudzivirira Zviratidzo Zvisati Zvaonekwa

Kune varidzi vezvipfuyo, kunzwisisa nzira idzi uye zvinokonzeresa zvinobvumira kudzivirira kuri nani:

Kana imbwa yako iri yeamhando ine njodzi hurukana ane anhoroondo yemhuri(dominant nhaka zvinoreva kuti hama dzinogona kutakura kuchinja kwakafanana), gara wazivisa veterinarians pamberi peanesthesia. Vanogona kusarudza mishonga isina njodzi (semuenzaniso, propofol, diazepam) uye kugadzirira maturusi ekutonhodza (mazaya echando, magumbeze ekutonhodza) nemishonga yekukurumidzira.

Dzivisakurovedza muviri kwakanyanyapanguva yekupisa.

Deredzahigh-stress situationskuderedza kuratidzwa kwe trigger.

Iko kukosha kweiyo nucleic acid yekuongororanokuti canine malignant hyperthermia iri mukuziva kana imbwa yako inotakura RYR1 mutation. Kusiyana nekuongororwa kwehutachiona, iyo inoona hutachiona, rudzi urwu rwebvunzo runoratidza njodzi yemajini. Kunyange kana imbwa iine asymptomatic nekuda kwekupinda kusina kukwana, kuziva chimiro chayo chekuberekwa kunobvumira varidzi kuti vagadzirise kutarisira uye zvisarudzo zvezvokurapa kuti vadzivise zvinokonzera-kuchengetedza mhuka dzemhuka dzakachengeteka kubva mumamiriro ezvinhu anotyisidzira upenyu.

Nguva yekutumira: Nov-13-2025